| Virtual Cell Published Models |
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| An open model of actin dendritic nucleation. |
| Ditlev, J.A., N.M. Vacanti, I.L. Novak, and L.M. Loew. |
| Biophys J. 2009 96:3529-3542. |
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| A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells. |
| Fridlyand LE, Jacobson DA, Kuznetsov A, Philipson LH. |
| Biophys J. 2009 Apr 22;96(8):3126-39. |
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| Energetic requirements for processive elongation of actin filaments by FH1FH2-formins |
| Aditya S. Paul and Thomas D. Pollard |
| J. Biol. Chem. 284:12533-40, 2009 |
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| Quantitative analysis of G-actin transport in motile cells
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| I.L. Novak, B.M. Slepchenko, A. Mogilner |
| Biophysical Journal, 95(4):1627-38, 2008 |
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| Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity |
| A.B. Goryachev, and A.V. Pokhilkos |
| FEBS Letters, v. 582, p.1437, (2008) |
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| Analysis of phosphatidylinositol-4,5-bisphosphate signaling in cerebellar Purkinje spines. |
| Brown, S., F. Morgan, J. Watras, and L.M. Loew. |
| Biophys J. 95:1795-1812,2008. |
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| Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. |
| Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. |
| Cell. 2008 May 16;133(4):666-80. |
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| The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. |
| Shen L, Weber CR, Turner JR. |
| J Cell Biol. 2008 May 19;181(4):683-95. Epub 2008 May 12. |
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| Calcium Transport Mechanisms of PC12 Cells. |
| Duman, J.G., L. Chen, and B. Hille. |
| J. Gen. Physiol. 131:307-323, 2008. |
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| Calcium signal transmission in chick sensory neurones is diffusion based. |
| Coatesworth W, Bolsover S. |
| Cell Calcium. 2008 Mar;43(3):236-49. Epub 2007 Jul 12 |
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| The role of the FH1 domain and profilin in formin-mediated actin-filament elongation and nucleation. |
| Paul, A., Pollard, T. |
| Current Biology, 2008 Jan 8;18(1):9-19. |
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| Membrane-binding/modification model of signaling protein activation and analysis of its control by cell morphology. |
| Haugh, J.M. |
| Biophys J 92, L93-95, 2007. |
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| Switching of membrane organelles between cytoskeletal transport systems is determined by regulation of the microtubule-based transport. |
| Slepchenko, B.M., Semenova, I., Zaliapin, I., and Rodionov, V. |
| J. Cell Biol., jcb.200705146, 2007. |
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| Regulation of cAMP dynamics by Ca2+ and G-protein coupled receptors in the pancreatic beta-cell: A computational approach. |
| Fridlyand, L.E., M.C. Harbeck, M.W. Roe, and L.H. Philipson |
| Am J Physiol Cell Physiol:293:C1924-C1933, 2007. |
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| Compartment-Specific Feedback Loop and Regulated Trafficking Can Result in Sustained Activation of Ras at the Golgi. |
| Narat J. Eungdamrong and Ravi Iyengar |
| Biophys. J. 2007; 92(3): p. 808-815 |
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| Does diacylglycerol regulate KCNQ channels? |
| Suh, B.-C., and B. Hille. |
| Pflügers Archiv European Journal of Physiology. 453:293-301,2006. |
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| Modeling the impact of store-operated Ca2+ entry on intracellular Ca2+ oscillations. |
| Kowalewski, J.M., P. Uhlen, H. Kitano, and H. Brismar. |
| Mathematical Biosciences. 204:232-249, 2006. |
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| In vivo dynamics of Rac-membrane interactions. |
| Moissoqlu K, Slepchenko BM, Meller N, Horwitz AF, Schwartz, MA |
| Mol Biol Cell. 2006 Jun; 17(6):2770-9. Epub 2006 Apr.5 |
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| Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. |
| J.J. Saucerman, J. Zhang, J.C. Martin, L.X. Peng, A.E. Stenbit, R.Y. Tsien, and A.D. McCulloch. |
| Proceedings of the National Academy of Sciences. 103:12923-12928. |
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| Analysis of a RanGTP-regulated gradient in mitotic somatic cells. |
Kalab, P., A. Pralle, E.Y. Isacoff, R. Heald, and K. Weis.
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Nature 2006. 440:(7084)697-701.
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| Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts. |
Schneider, I.C. and Haugh, J.M.
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J.Cell B 171:883-892 (2005)
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| Modeling and Analysis of Calcium Signaling Events Leading to Long-Term Depression in Cerebellar Purkinje Cells. |
N. Hernjak, B. M. Slepchenko, K. Fernald, C.C. Fink, D. Fortin, I.I. Moraru, J. Watras, and L.M. Loew.
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Biophysical Journal Volume 89, Dec. 2005, pp. 3790-3806
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| STAT module can function as a biphasic amplitude filter. |
V. Mayya and L.M. Loew.
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IEE Proceedings Systems Biology, March 2005, Volume 2, Issue 1, p. 43-52
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| Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current. |
Horowitz LF, Hirdes W, Suh B-C, Hilgemann DW, Mackie K, Hille B.
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J. Gen. Physiol. 2005. 126(3):243-262.
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| Rearrangement of the endoplasmic reticulum and calcium transient formation: The computational approach. |
| Pomorski P, Targos B, Baranska J. |
| Biochem Biophys Res Commun. 2005 Mar 25;328(4):1126-32. |
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| Bio-switches: what makes them robust? |
| Slepchenko, B. M. and Terasaki, M. |
| Opin. Genet. Dev. 2004; 14/4: 428-434. |
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| A multi-enzyme model for pyrosequencing. |
Ali Agah, Mariam Aghajan, Foad Mashayekhi, Sasan Amini, Ronald W. Davis, James D. Plummer, Mostafa Ronaghi, and Peter B. Griffin.
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Nucleic Acids Research 2004 32(21):e166
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Two Complementary, Local Excitation, Global Inhibition Mechanisms Acting in Parallel Can Explain the Chemoattractant-Induced Regulation of PI(3,4,5)P3 Response in Dictyostelium Cells.
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Lan Ma, Chris Janetopoulos, Liu Yang, Peter N. Devreotes and Pablo A. Iglesias.
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Biophys. J. 2004; 87(6): p. 3764-3774
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| A Signal Transduction Pathway Model Prototype I: Application to Ca2+-Calmodulin Signaling and Myosin Light Chain Phosphorylation. |
| Lukas, TJ |
Biophys. J. 2004;87 1417-1425
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| A Signal Transduction Pathway Model Prototype I: From Agonist to Cellular Endpoint. |
Lukas, TJ
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Biophys. J. 2004; 87 1406-1416
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High Mobility of Vesicles Supports Continuous Exocytosis at a Ribbon Synapse.
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Matthew Holt, Anne Cooke, Andreas Neef, and Leon Lagnado.
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Current Biology, Vol. 14, 173-183, February 3, 2004
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Regulation of KCNQ2/KCNQ3 Current by G Protein Cycling: the kinetics of receptor-mediated signaling by Gq.
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Byung-Chang Suh, Lisa R. Horowitz, Wiebke Hirdes, Ken Mackie and Bertil Hille.
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Journal of General Physiology, Volume 123, Number 6, June 2004 663-683
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| Cyclin aggregation and robustness of bio-switching. |
| Slepchenko, B. M. and Terasaki, M. |
Mol. Biol. Cell 2003;14: 4695 - 4706.
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Kinetic analysis of receptor-activated phosphoinositide turnover
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Chang Xu, James Watras and Leslie M. Loew
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Journal of Cell Biology, vol. 161, no. 4, May 26, 2003
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Centrosome positioning in interphase cells.
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Anton Burakov, Elena Nadezhdina, Boris Slepchenko, and Vladimir Rodionov
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Journal of Cell Biology, 2003 Sep 15;162(6):963-9.
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Modeling Ca2+ flux in pancreatic B-cells: role of the plasma membrane and intracellular stores.
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Leonid E. Fridlyand, Natalia Tamarina, and Louis H. Philipson
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Am J Physiol Endocrinol Metab, Jul 2003;285: E138-154
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Systems Analysis of Ran Transport
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Alicia E. Smith, Boris M. Slepchenko, James C. Schaff, Leslie M. Loew, Ian G. Macara.
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Science. 2002 Jan 18;295(5554):488-91
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Local Photorelease of Caged Thymosin beta4 in Locomoting Keratocytes Causes Cell Turning.
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Roy P, Rajfur Z, Jones D, Marriott G, Loew L, Jacobson K.
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J Cell Biol. 2001 May 28;153(5):1035-48
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An image-based model of calcium waves in differentiated neuroblastoma cells.
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| Fink, C. C., B. Slepchenko, I. I. Moraru, J. Watras, J. Schaff, and L. M. Loew. |
Biophys. J. 2000 79:163-183.2000.
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Morphological control of inositol-1,4,5-trisphosphate-dependent signals.
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Fink, C. C., B. Slepchenko, I. I. Moraru, J. Schaff, J. Watras, and L. M. Loew.
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J. Cell Biol. 147:929-936, 1999.
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Computational Cell Biology
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Christopher P. Fall, Eric S. Marland, John M. Wagner, John J. Tyson.
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