<BioModel Annotation='This model is intended for anlaysis of PH-GFP experiments and includes binding of the probe to both PIP2 on the plasma membrane and IP3 in the cytosol. The system is based on bradykinin induced calcium release mediated by IP3 in N1E-115 neuroblastoma cells.' Name='PIP2 Hydrolysis JCB Submission'>
  <Model Annotation='' Name='unnamed'>
    <Compound Annotation='PIP2_PHGFP' Name='PIP2_PHGFP' />
    <Compound Annotation='Pleckstrin homology domain_GFP' Name='PH_GFP' />
    <Compound Annotation='Phosphatidylinositol' Name='PI' />
    <Compound Annotation='stimulus' Name='stim' />
    <Compound Annotation='IP3_PHGFP' Name='IP3_PHGFP' />
    <Compound Annotation='Phosphatidylinositolbisphosphate' Name='PIP2' />
    <Compound Annotation='Phosphatidylinositol 4-phosphate' Name='PIP' />
    <Compound Annotation='Diacylglycerol' Name='DAG' />
    <Compound Annotation='photon' Name='hv' />
    <Compound Annotation='Caged_IP3' Name='IP3X' />
    <Compound Annotation='Phospholipase C' Name='PLC' />
    <Compound Annotation='1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase' Name='PLC_act' />
    <Compound Annotation='Inositol-1,4,5-trisphosphate' Name='IP3' />
    <Feature Name='Cytosol' />
    <Feature Name='Nucleus' />
    <Feature Name='Extraclellular' />
    <Membrane InsideFeature='Nucleus' OutsideFeature='Cytosol' MembraneVoltage='Voltage_Membrane0' Name='NM' />
    <Membrane InsideFeature='Cytosol' OutsideFeature='Extraclellular' MembraneVoltage='Voltage_Membrane0' Name='PM' />
    <LocalizedCompound CompoundRef='PIP2_PHGFP' OverrideName='false' Structure='PM' Name='PIP2_PHGFP_PM' />
    <LocalizedCompound CompoundRef='PH_GFP' OverrideName='true' Structure='Cytosol' Name='PH_GFP_Cyt' />
    <LocalizedCompound CompoundRef='PI' OverrideName='false' Structure='PM' Name='PI_PM' />
    <LocalizedCompound CompoundRef='stim' OverrideName='false' Structure='PM' Name='stim_PM' />
    <LocalizedCompound CompoundRef='IP3_PHGFP' OverrideName='true' Structure='Cytosol' Name='IP3_PHGFP_Cyt' />
    <LocalizedCompound CompoundRef='PIP2' OverrideName='false' Structure='PM' Name='PIP2_PM' />
    <LocalizedCompound CompoundRef='PIP' OverrideName='false' Structure='PM' Name='PIP_PM' />
    <LocalizedCompound CompoundRef='DAG' OverrideName='false' Structure='PM' Name='DAG_PM' />
    <LocalizedCompound CompoundRef='hv' OverrideName='false' Structure='Cytosol' Name='hv_Cytosol' />
    <LocalizedCompound CompoundRef='IP3X' OverrideName='false' Structure='Cytosol' Name='IP3X_Cytosol' />
    <LocalizedCompound CompoundRef='PLC' OverrideName='false' Structure='PM' Name='PLC_PM' />
    <LocalizedCompound CompoundRef='PLC_act' OverrideName='false' Structure='PM' Name='PLC_act_PM' />
    <LocalizedCompound CompoundRef='IP3' OverrideName='true' Structure='Cytosol' Name='IP3_Cyt' />
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='Cytosol' Name='IP3deg'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='IP3_Cyt' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Parameter>
        <Parameter Name='kIP3deg'>0.16</Parameter>
        <Parameter Name='IP3_basal'>0.16</Parameter>
        <Rate>Rate_IP3deg</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='Cytosol' Name='IP3-PHGFP'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='IP3_Cyt' />
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PH_GFP_Cyt' />
      <Product Stoichiometry='1' LocalizedCompoundRef='IP3_PHGFP_Cyt' />
      <Kinetics KineticsType='MassAction'>
        <Parameter Name='kf_IP3PH'>100.0</Parameter>
        <Parameter Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Parameter>
        <Parameter Name='KdIP3PH'>2.0</Parameter>
        <ForwardRate>kf_IP3PH</ForwardRate>
        <ReverseRate>kr_IP3PH</ReverseRate>
        <Rate>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PIP2_PH'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PH_GFP_Cyt' />
      <Product Stoichiometry='1' LocalizedCompoundRef='PIP2_PHGFP_PM' />
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PIP2_PM' />
      <Kinetics KineticsType='MassAction'>
        <Parameter Name='kf_PIP2PH'>200.0</Parameter>
        <Parameter Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Parameter>
        <Parameter Name='KdPIP2PH'>2.0</Parameter>
        <ForwardRate>kf_PIP2PH</ForwardRate>
        <ReverseRate>kr_PIP2PH</ReverseRate>
        <Rate>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PIP2Syn'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PIP_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='PIP2_PM' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Parameter>
        <Parameter Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Parameter>
        <Parameter Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Parameter>
        <Parameter Name='kBasalSynPIP2'>0.045</Parameter>
        <Parameter Name='PIP2_basal'>1072.0</Parameter>
        <Parameter Name='kStimSynPIP2'>0.01</Parameter>
        <Parameter Name='tauPIP2syn'>0.05</Parameter>
        <Parameter Name='PIP2syndecay'>10.0</Parameter>
        <Rate>Rate_PIP2Syn</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PIPSyn'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PI_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='PIP_PM' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Parameter>
        <Parameter Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Parameter>
        <Parameter Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Parameter>
        <Parameter Name='kBasalSynPIP'>0.0015</Parameter>
        <Parameter Name='PIP_basal'>2857.0</Parameter>
        <Parameter Name='kStimSynPIP'>0.01</Parameter>
        <Parameter Name='tauPIPsyn'>0.05</Parameter>
        <Parameter Name='PIPsyndecay'>10.0</Parameter>
        <Rate>Rate_PIPSyn</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PIP2_hyd'>
      <Product Stoichiometry='1' LocalizedCompoundRef='DAG_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='IP3_Cyt' />
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PIP2_PM' />
      <Modifier LocalizedCompoundRef='PLC_act_PM' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Parameter>
        <Parameter Name='k_PIP2hyd'>1.188</Parameter>
        <Rate>Rate_PIP2_hyd</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='Cytosol' Name='IP3_uncaging'>
      <Product Stoichiometry='1' LocalizedCompoundRef='IP3_Cyt' />
      <Modifier LocalizedCompoundRef='hv_Cytosol' />
      <Reactant Stoichiometry='1' LocalizedCompoundRef='IP3X_Cytosol' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='J_IP3_uncaging'>(intensity * IP3X_Cytosol * hv_Cytosol)</Parameter>
        <Parameter Name='intensity'>100000.0</Parameter>
        <Rate>J_IP3_uncaging</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PLCact'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PLC_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='PLC_act_PM' />
      <Modifier LocalizedCompoundRef='stim_PM' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Parameter>
        <Parameter Name='KfPLCact'>1000.0</Parameter>
        <Parameter Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Parameter>
        <Parameter Name='krPLCact'>10.0</Parameter>
        <Parameter Name='tau0'>0.05</Parameter>
        <Parameter Name='stimdecay'>6.0</Parameter>
        <Rate>RatePLCact</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PIP2_PH_hyd'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PIP2_PHGFP_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='PH_GFP_Cyt' />
      <Product Stoichiometry='1' LocalizedCompoundRef='IP3_Cyt' />
      <Modifier LocalizedCompoundRef='PLC_act_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='DAG_PM' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Parameter>
        <Parameter Name='k_PIP2PHhyd'>50.0</Parameter>
        <Rate>RatePIP2_PH_hyd</Rate>
      </Kinetics>
    </SimpleReaction>
    <Diagram Structure='PM' Name='Membrane0'>
      <LocalizedCompoundShape LocationX='177' LocationY='305' LocalizedCompoundRef='PIP2_PHGFP_PM' />
      <LocalizedCompoundShape LocationX='49' LocationY='54' LocalizedCompoundRef='PI_PM' />
      <LocalizedCompoundShape LocationX='123' LocationY='342' LocalizedCompoundRef='stim_PM' />
      <LocalizedCompoundShape LocationX='25' LocationY='350' LocalizedCompoundRef='PIP2_PM' />
      <LocalizedCompoundShape LocationX='66' LocationY='182' LocalizedCompoundRef='PIP_PM' />
      <LocalizedCompoundShape LocationX='331' LocationY='429' LocalizedCompoundRef='DAG_PM' />
      <LocalizedCompoundShape LocationX='143' LocationY='410' LocalizedCompoundRef='PLC_PM' />
      <LocalizedCompoundShape LocationX='247' LocationY='407' LocalizedCompoundRef='PLC_act_PM' />
      <LocalizedCompoundShape LocationX='41' LocationY='160' LocalizedCompoundRef='PH_GFP_Cyt' />
      <LocalizedCompoundShape LocationX='30' LocationY='102' LocalizedCompoundRef='IP3_PHGFP_Cyt' />
      <LocalizedCompoundShape LocationX='60' LocationY='50' LocalizedCompoundRef='hv_Cytosol' />
      <LocalizedCompoundShape LocationX='18' LocationY='49' LocalizedCompoundRef='IP3X_Cytosol' />
      <LocalizedCompoundShape LocationX='43' LocationY='448' LocalizedCompoundRef='IP3_Cyt' />
      <SimpleReactionShape LocationX='274' LocationY='231' SimpleReactionRef='PIP2_PH' />
      <SimpleReactionShape LocationX='76' LocationY='247' SimpleReactionRef='PIP2Syn' />
      <SimpleReactionShape LocationX='54' LocationY='122' SimpleReactionRef='PIPSyn' />
      <SimpleReactionShape LocationX='177' LocationY='473' SimpleReactionRef='PIP2_hyd' />
      <SimpleReactionShape LocationX='183' LocationY='395' SimpleReactionRef='PLCact' />
      <SimpleReactionShape LocationX='273' LocationY='329' SimpleReactionRef='PIP2_PH_hyd' />
    </Diagram>
    <Diagram Structure='Extraclellular' Name='unnamed' />
    <Diagram Structure='NM' Name='Membrane0' />
    <Diagram Structure='Cytosol' Name='Feature0'>
      <LocalizedCompoundShape LocationX='153' LocationY='155' LocalizedCompoundRef='IP3_Cyt' />
      <LocalizedCompoundShape LocationX='27' LocationY='21' LocalizedCompoundRef='PLC_Cyt' />
      <LocalizedCompoundShape LocationX='107' LocationY='286' LocalizedCompoundRef='PH_GFP_Cyt' />
      <LocalizedCompoundShape LocationX='321' LocationY='233' LocalizedCompoundRef='IP3_PHGFP_Cyt' />
      <LocalizedCompoundShape LocationX='110' LocationY='39' LocalizedCompoundRef='hv_Cytosol' />
      <LocalizedCompoundShape LocationX='36' LocationY='79' LocalizedCompoundRef='IP3X_Cytosol' />
      <SimpleReactionShape LocationX='249' LocationY='97' SimpleReactionRef='IP3deg' />
      <SimpleReactionShape LocationX='206' LocationY='229' SimpleReactionRef='IP3-PHGFP' />
      <SimpleReactionShape LocationX='80' LocationY='102' SimpleReactionRef='reaction0' />
    </Diagram>
    <Diagram Structure='Nucleus' Name='Feature0' />
    <Version FromVersionable='true' Name='unnamed'></Version>
  </Model>
  <SimulationSpec Annotation='' Name='steady state compartment'>
    <Geometry Dimension='0' Annotation='' Name='steady state compartment'>
      <Extent X='10.0' Y='10.0' Z='10.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <SubVolume Handle='0' Type='Compartmental' Name='Compartment' />
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='false' Feature='Cytosol' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Nucleus' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Extraclellular' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.1' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='0.263' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.8' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>1200000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>12000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='fast' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='steady state compartment'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='kBasalSynPIP'>0.0015</Constant>
      <Constant Name='PLC_PM_init'>0.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='intensity'>100000.0</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>0.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='PIP2syndecay'>10.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>0.0</Constant>
      <Constant Name='PIP_basal'>2857.0</Constant>
      <Constant Name='PIPsyndecay'>10.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>0.0</Constant>
      <Constant Name='kStimSynPIP'>0.01</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>1200000.0</Constant>
      <Constant Name='k_PIP2hyd'>1.188</Constant>
      <Constant Name='PH_GFP_Cyt_init'>1.0</Constant>
      <Constant Name='SurfToVol_PM'>0.263</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='PI_PM'>1200000.0</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>0.0</Constant>
      <Constant Name='PIP2_PM_init'>12000.0</Constant>
      <Constant Name='VolFract_Nucleus'>0.1</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='VolFract_Cytosol'>0.8</Constant>
      <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
      <Constant Name='kStimSynPIP2'>0.01</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='PH_GFP_Cyt'>1.0</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='SurfToVol_NM'>1.0</Constant>
      <Constant Name='tauPIPsyn'>0.05</Constant>
      <Constant Name='stim_PM_init'>0.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>0.0</Constant>
      <Constant Name='PIP2_basal'>1072.0</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='kBasalSynPIP2'>0.045</Constant>
      <Constant Name='PIP2_PM'>12000.0</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='IP3_Cyt'>0.16</Constant>
      <Constant Name='k_PIP2PHhyd'>50.0</Constant>
      <Constant Name='tauPIP2syn'>0.05</Constant>
      <VolumeVariable Name='IP3_PHGFP_Cyt' />
      <VolumeVariable Name='PIP2_PHGFP_PM' />
      <VolumeVariable Name='IP3X_Cytosol' />
      <VolumeVariable Name='PLC_act_PM' />
      <VolumeVariable Name='PIP_PM' />
      <VolumeVariable Name='DAG_PM' />
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Function>
      <Function Name='K_PLC_PM_total'>((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PLC_PM'>((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Function>
      <Function Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Function>
      <Function Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Function>
      <Function Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Function>
      <Function Name='K_hv_Cytosol_total'>(hv_Cytosol_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)</Function>
      <Function Name='hv_Cytosol'>(K_hv_Cytosol_total / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Function>
      <Function Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Function>
      <Function Name='Kflux_NM_Nucleus'>SurfToVol_NM</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Function>
      <Function Name='Kflux_NM_Cytosol'>(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Kflux_PM_Cytosol'>(SurfToVol_PM / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Function>
      <Function Name='Kflux_PM_Extraclellular'>(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))</Function>
      <Function Name='J_IP3_uncaging'>(intensity * IP3X_Cytosol * hv_Cytosol)</Function>
      <Function Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Function>
      <CompartmentSubDomain Name='Compartment'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <OdeEquation Name='IP3_PHGFP_Cyt'>
          <Rate>0.0</Rate>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='IP3X_Cytosol'>
          <Rate> - J_IP3_uncaging</Rate>
          <Initial>IP3X_Cytosol_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PHGFP_PM'>
          <Rate>(J_PIP2_PH - RatePIP2_PH_hyd)</Rate>
          <Initial>PIP2_PHGFP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP_PM'>
          <Rate>( - Rate_PIP2Syn + Rate_PIPSyn)</Rate>
          <Initial>PIP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>(Rate_PIP2_hyd + RatePIP2_PH_hyd)</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
        <FastSystem>
          <FastRate>J_IP3_PHGFP</FastRate>
        </FastSystem>
      </CompartmentSubDomain>
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </MathDescription>
    <Simulation Annotation='Total PIP2 + both complexes =&amp;#10;12,000molec/um2' Name='ss check 1'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='Runge-Kutta-Fehlberg (Fifth Order, Variable Time Step)' KeepEvery='1'>
        <TimeBound StartTime='0.0' EndTime='1.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-8' DefaultTime='0.1' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='PIP2_PM'>4000.0</Constant>
        <Constant Name='intensity'>100000.0</Constant>
        <Constant Name='kf_IP3PH'>100.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='kIP3deg'>0.16</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP_PM_init'>0.0</Constant>
        <Constant Name='kStimSynPIP'>0.01</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='PIPsyndecay'>10.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kBasalSynPIP'>0.0015</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='PI_PM'>142857.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='stim_PM'>0.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='krPLCact'>10.0</Constant>
        <Constant Name='kStimSynPIP2'>0.01</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='k_PIP2hyd'>1.188</Constant>
        <Constant Name='kBasalSynPIP2'>0.045</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='KfPLCact'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='stimdecay'>6.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='IP3_Cyt'>0.16</Constant>
        <Constant Name='PIP2syndecay'>10.0</Constant>
        <Constant Name='kf_PIP2PH'>200.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='stim_PM_init'>0.0</Constant>
        <Constant Name='PH_GFP_Cyt'>2.30769</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='k_PIP2PHhyd'>50.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='SurfToVol_PM'>0.263</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='ss check 1'>Total PIP2 + both complexes =&amp;#10;12,000molec/um2</Version>
    </Simulation>
    <Version FromVersionable='true' Name='steady state compartment'></Version>
  </SimulationSpec>
  <SimulationSpec Annotation='(copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) ' Name='uncaging'>
    <Geometry Dimension='0' Annotation='' Name='steady state compartment'>
      <Extent X='10.0' Y='10.0' Z='10.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <SubVolume Handle='0' Type='Compartmental' Name='Compartment' />
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='false' Feature='Cytosol' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Nucleus' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Extraclellular' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.1' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='0.263' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.8' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>2.30769</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>3.6923</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>1.01446</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>4617.4</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>142857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>4000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>2857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>100.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='Average Exp Params - fast off'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='PLC_PM_init'>100.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='intensity'>100000.0</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>1.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>1.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>142857.0</Constant>
      <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
      <Constant Name='hv_Cytosol'>1.0</Constant>
      <Constant Name='SurfToVol_PM'>0.263</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>2857.0</Constant>
      <Constant Name='PIP2_PM_init'>4000.0</Constant>
      <Constant Name='VolFract_Nucleus'>0.1</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='VolFract_Cytosol'>0.8</Constant>
      <Constant Name='IP3X_Cytosol_init'>1.01446</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='SurfToVol_NM'>1.0</Constant>
      <Constant Name='stim_PM_init'>1.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='k_PIP2PHhyd'>50.0</Constant>
      <VolumeVariable Name='IP3_PHGFP_Cyt' />
      <VolumeVariable Name='IP3X_Cytosol' />
      <VolumeVariable Name='PLC_act_PM' />
      <VolumeVariable Name='DAG_PM' />
      <VolumeVariable Name='PIP2_PM' />
      <VolumeVariable Name='IP3_Cyt' />
      <Function Name='K_PI_PM_total'>(PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE)</Function>
      <Function Name='K_PH_GFP_Cyt_total'>( - (DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='PH_GFP_Cyt'>(((DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='K_PIP2_PHGFP_PM_total'>((DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PIP2_PHGFP_PM'>(( - (DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PIP2_PHGFP_PM_total - (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='K_PLC_PM_total'>((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PLC_PM'>((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='K_PIP_PM_total'>(PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE)</Function>
      <Function Name='PIP_PM'>(K_PIP_PM_total / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='Kflux_NM_Nucleus'>SurfToVol_NM</Function>
      <Function Name='PI_PM'>(K_PI_PM_total / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Function>
      <Function Name='Kflux_NM_Cytosol'>(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Kflux_PM_Cytosol'>(SurfToVol_PM / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Function>
      <Function Name='Kflux_PM_Extraclellular'>(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))</Function>
      <Function Name='J_IP3_uncaging'>(intensity * IP3X_Cytosol * hv_Cytosol)</Function>
      <Function Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Function>
      <CompartmentSubDomain Name='Compartment'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <OdeEquation Name='IP3_PHGFP_Cyt'>
          <Rate>J_IP3_PHGFP</Rate>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='IP3X_Cytosol'>
          <Rate> - J_IP3_uncaging</Rate>
          <Initial>IP3X_Cytosol_init</Initial>
        </OdeEquation>
        <OdeEquation Name='IP3_Cyt'>
          <Rate>((RatePIP2_PH_hyd * Kflux_PM_Cytosol * KMOLE) + J_IP3_uncaging - Rate_IP3deg - J_IP3_PHGFP)</Rate>
          <Initial>IP3_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PM'>
          <Rate> - J_PIP2_PH</Rate>
          <Initial>PIP2_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>RatePIP2_PH_hyd</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
      </CompartmentSubDomain>
      <Version FromVersionable='true' Name='Average Exp Params - fast off'></Version>
    </MathDescription>
    <Simulation Annotation='' Name='First Try'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KfPLCact'>0.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='hv_Cytosol_init'>1.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='hv_Cytosol'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='stim_PM_init'>0.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='tau0'>0.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='stimdecay'>6.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='intensity'>100000.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stim_PM'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='krPLCact'>10.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>1.01446</Constant>
        <Constant Name='_R_'>8314.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='First Try'></Version>
    </Simulation>
    <Simulation Annotation='' Name='3X PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KfPLCact'>0.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 3.0)</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='hv_Cytosol_init'>1.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='hv_Cytosol'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='stim_PM_init'>0.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 3.0)</Constant>
        <Constant Name='tau0'>0.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='stimdecay'>6.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='intensity'>100000.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stim_PM'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='krPLCact'>10.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 3.0)</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>1.01446</Constant>
        <Constant Name='_R_'>8314.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='3X PH-GFP'></Version>
    </Simulation>
    <Simulation Annotation='' Name='0.3X PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KfPLCact'>0.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 0.3)</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='hv_Cytosol_init'>1.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='hv_Cytosol'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='stim_PM_init'>0.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 0.3)</Constant>
        <Constant Name='tau0'>0.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='stimdecay'>6.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='intensity'>100000.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stim_PM'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='krPLCact'>10.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 0.3)</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>1.01446</Constant>
        <Constant Name='_R_'>8314.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='0.3X PH-GFP'></Version>
    </Simulation>
    <Simulation Annotation='' Name='SS check - 0 IP3X_Cyt'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KfPLCact'>0.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='hv_Cytosol_init'>1.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='hv_Cytosol'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='stim_PM_init'>0.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='tau0'>0.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='stimdecay'>6.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='kIP3deg'>0.16</Constant>
        <Constant Name='intensity'>100000.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stim_PM'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='krPLCact'>10.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='SS check - 0 IP3X_Cyt'></Version>
    </Simulation>
    <Version FromVersionable='true' Name='uncaging'>(copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) </Version>
  </SimulationSpec>
  <SimulationSpec Annotation='(copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) ' Name='Compartmental Sim'>
    <Geometry Dimension='0' Annotation='' Name='steady state compartment'>
      <Extent X='10.0' Y='10.0' Z='10.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <SubVolume Handle='0' Type='Compartmental' Name='Compartment' />
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='false' Feature='Cytosol' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Nucleus' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Extraclellular' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.1' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='0.263' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.8' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>5.46296</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>0.437037</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>2928.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>142857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>1072.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>2857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>100.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='Compartmental Sim'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='kBasalSynPIP'>0.0015</Constant>
      <Constant Name='PLC_PM_init'>100.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>0.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='PIP2syndecay'>10.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>1.0</Constant>
      <Constant Name='PIP_basal'>2857.0</Constant>
      <Constant Name='PIPsyndecay'>10.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>0.437037</Constant>
      <Constant Name='IP3X_Cytosol'>0.0</Constant>
      <Constant Name='kStimSynPIP'>0.01</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>142857.0</Constant>
      <Constant Name='k_PIP2hyd'>1.188</Constant>
      <Constant Name='PH_GFP_Cyt_init'>5.46296</Constant>
      <Constant Name='hv_Cytosol'>0.0</Constant>
      <Constant Name='SurfToVol_PM'>0.263</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>2857.0</Constant>
      <Constant Name='PIP2_PM_init'>1072.0</Constant>
      <Constant Name='VolFract_Nucleus'>0.1</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='VolFract_Cytosol'>0.8</Constant>
      <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
      <Constant Name='kStimSynPIP2'>0.01</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='SurfToVol_NM'>1.0</Constant>
      <Constant Name='tauPIPsyn'>0.05</Constant>
      <Constant Name='stim_PM_init'>1.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>2928.0</Constant>
      <Constant Name='PIP2_basal'>1072.0</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='kBasalSynPIP2'>0.045</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='k_PIP2PHhyd'>50.0</Constant>
      <Constant Name='tauPIP2syn'>0.05</Constant>
      <VolumeVariable Name='IP3_PHGFP_Cyt' />
      <VolumeVariable Name='PLC_act_PM' />
      <VolumeVariable Name='PIP_PM' />
      <VolumeVariable Name='PI_PM' />
      <VolumeVariable Name='DAG_PM' />
      <VolumeVariable Name='PIP2_PM' />
      <VolumeVariable Name='IP3_Cyt' />
      <Function Name='K_PH_GFP_Cyt_total'>( - (DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='PH_GFP_Cyt'>(((DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='K_PIP2_PHGFP_PM_total'>((DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PIP2_PHGFP_PM'>(( - (DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PIP2_PHGFP_PM_total - (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Function>
      <Function Name='K_PLC_PM_total'>((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PLC_PM'>((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Function>
      <Function Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Function>
      <Function Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Function>
      <Function Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Function>
      <Function Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Function>
      <Function Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Function>
      <Function Name='Kflux_NM_Nucleus'>SurfToVol_NM</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Function>
      <Function Name='Kflux_NM_Cytosol'>(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Kflux_PM_Cytosol'>(SurfToVol_PM / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Function>
      <Function Name='Kflux_PM_Extraclellular'>(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))</Function>
      <Function Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Function>
      <CompartmentSubDomain Name='Compartment'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <OdeEquation Name='IP3_PHGFP_Cyt'>
          <Rate>J_IP3_PHGFP</Rate>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='IP3_Cyt'>
          <Rate>((RatePIP2_PH_hyd * Kflux_PM_Cytosol * KMOLE) + (Rate_PIP2_hyd * Kflux_PM_Cytosol * KMOLE) - Rate_IP3deg - J_IP3_PHGFP)</Rate>
          <Initial>IP3_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PI_PM'>
          <Rate> - Rate_PIPSyn</Rate>
          <Initial>PI_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PM'>
          <Rate>( - Rate_PIP2_hyd - J_PIP2_PH + Rate_PIP2Syn)</Rate>
          <Initial>PIP2_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP_PM'>
          <Rate>( - Rate_PIP2Syn + Rate_PIPSyn)</Rate>
          <Initial>PIP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>(Rate_PIP2_hyd + RatePIP2_PH_hyd)</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
      </CompartmentSubDomain>
      <Version FromVersionable='true' Name='Compartmental Sim'></Version>
    </MathDescription>
    <Simulation Annotation='S:V=.5&amp;#10;optimized rates&amp;#10;' Name='no PHGFP,  S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-11' Absolut='1.0E-11' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='KdIP3PH'>2.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>0.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>0.0</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='no PHGFP,  S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>S:V=.5&amp;#10;optimized rates&amp;#10;</Version>
    </Simulation>
    <Simulation Annotation='S:V=.5&amp;#10;optimized rates&amp;#10;' Name='PHGFP, KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-11' Absolut='1.0E-11' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='PHGFP, KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>S:V=.5&amp;#10;optimized rates&amp;#10;</Version>
    </Simulation>
    <Simulation Annotation='S:V=.5&amp;#10;optimized rates&amp;#10;' Name='KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt, 3X PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-11' Absolut='1.0E-11' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 3.0)</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 3.0)</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 3.0)</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt, 3X PH-GFP'>S:V=.5&amp;#10;optimized rates&amp;#10;</Version>
    </Simulation>
    <Simulation Annotation='S:V=.5&amp;#10;optimized rates&amp;#10;' Name='KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt, 0.3X PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-11' Absolut='1.0E-11' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 0.3)</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 0.3)</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 0.3)</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt, 0.3X PH-GFP'>S:V=.5&amp;#10;optimized rates&amp;#10;</Version>
    </Simulation>
    <Simulation Annotation='S:V=.5&amp;#10;optimized rates&amp;#10;' Name='copy of PHGFP, KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-11' Absolut='1.0E-11' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='kStimSynPIP2'>0.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='kStimSynPIP'>0.0</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='copy of PHGFP, KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>S:V=.5&amp;#10;optimized rates&amp;#10;</Version>
    </Simulation>
    <Version FromVersionable='true' Name='Compartmental Sim'>(copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) </Version>
  </SimulationSpec>
  <SimulationSpec Annotation='(copied from Compartmental Sim) (copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) ' Name='Comp Fixed IP3'>
    <Geometry Dimension='0' Annotation='' Name='steady state compartment'>
      <Extent X='10.0' Y='10.0' Z='10.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <SubVolume Handle='0' Type='Compartmental' Name='Compartment' />
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='false' Feature='Cytosol' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Nucleus' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Extraclellular' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.1' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='0.5' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.8' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>2.30769</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>3.6923</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>4617.4</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>142857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>4000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>2857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>100.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='Comp Fixed IP3'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='kBasalSynPIP'>0.0015</Constant>
      <Constant Name='PLC_PM_init'>100.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>0.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='PIP2syndecay'>10.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>1.0</Constant>
      <Constant Name='PIP_basal'>2857.0</Constant>
      <Constant Name='PIPsyndecay'>10.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
      <Constant Name='IP3X_Cytosol'>0.0</Constant>
      <Constant Name='kStimSynPIP'>0.01</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>142857.0</Constant>
      <Constant Name='k_PIP2hyd'>1.188</Constant>
      <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
      <Constant Name='hv_Cytosol'>0.0</Constant>
      <Constant Name='SurfToVol_PM'>0.5</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>2857.0</Constant>
      <Constant Name='PIP2_PM_init'>4000.0</Constant>
      <Constant Name='VolFract_Nucleus'>0.1</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='VolFract_Cytosol'>0.8</Constant>
      <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
      <Constant Name='kStimSynPIP2'>0.01</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='SurfToVol_NM'>1.0</Constant>
      <Constant Name='tauPIPsyn'>0.05</Constant>
      <Constant Name='stim_PM_init'>1.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
      <Constant Name='PIP2_basal'>1072.0</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='kBasalSynPIP2'>0.045</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='IP3_Cyt'>0.16</Constant>
      <Constant Name='k_PIP2PHhyd'>50.0</Constant>
      <Constant Name='tauPIP2syn'>0.05</Constant>
      <VolumeVariable Name='IP3_PHGFP_Cyt' />
      <VolumeVariable Name='PLC_act_PM' />
      <VolumeVariable Name='PIP_PM' />
      <VolumeVariable Name='PI_PM' />
      <VolumeVariable Name='DAG_PM' />
      <VolumeVariable Name='PIP2_PM' />
      <Function Name='K_PH_GFP_Cyt_total'>( - (DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='PH_GFP_Cyt'>(((DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='K_PIP2_PHGFP_PM_total'>((DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PIP2_PHGFP_PM'>(( - (DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PIP2_PHGFP_PM_total - (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Function>
      <Function Name='K_PLC_PM_total'>((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PLC_PM'>((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Function>
      <Function Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Function>
      <Function Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Function>
      <Function Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Function>
      <Function Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Function>
      <Function Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Function>
      <Function Name='Kflux_NM_Nucleus'>SurfToVol_NM</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Function>
      <Function Name='Kflux_NM_Cytosol'>(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Kflux_PM_Cytosol'>(SurfToVol_PM / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Function>
      <Function Name='Kflux_PM_Extraclellular'>(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))</Function>
      <Function Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Function>
      <CompartmentSubDomain Name='Compartment'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <OdeEquation Name='IP3_PHGFP_Cyt'>
          <Rate>J_IP3_PHGFP</Rate>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PI_PM'>
          <Rate> - Rate_PIPSyn</Rate>
          <Initial>PI_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PM'>
          <Rate>( - Rate_PIP2_hyd - J_PIP2_PH + Rate_PIP2Syn)</Rate>
          <Initial>PIP2_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP_PM'>
          <Rate>( - Rate_PIP2Syn + Rate_PIPSyn)</Rate>
          <Initial>PIP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>(Rate_PIP2_hyd + RatePIP2_PH_hyd)</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
      </CompartmentSubDomain>
      <Version FromVersionable='true' Name='Comp Fixed IP3'></Version>
    </MathDescription>
    <Simulation Annotation='' Name='Fixed IP3'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='IP3_Cyt'>0.16</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed IP3'></Version>
    </Simulation>
    <Simulation Annotation='' Name='Fixed IP3, 3x PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 3.0)</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 3.0)</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='IP3_Cyt'>0.16</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 3.0)</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed IP3, 3x PH-GFP'></Version>
    </Simulation>
    <Simulation Annotation='' Name='Fixed IP3, 0.3x PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 0.3)</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 0.3)</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='IP3_Cyt'>0.16</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 0.3)</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed IP3, 0.3x PH-GFP'></Version>
    </Simulation>
    <Simulation Annotation='' Name='Fixed IP3 Increase Affinity for PIP2'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>0.1</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='IP3_Cyt'>0.16</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>92307.6</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed IP3 Increase Affinity for PIP2'></Version>
    </Simulation>
    <Version FromVersionable='true' Name='Comp Fixed IP3'>(copied from Compartmental Sim) (copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) </Version>
  </SimulationSpec>
  <SimulationSpec Annotation='(copied from Comp Fixed IP3) (copied from Compartmental Sim) (copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) ' Name='Comp Fixed PIP2'>
    <Geometry Dimension='0' Annotation='' Name='steady state compartment'>
      <Extent X='10.0' Y='10.0' Z='10.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <SubVolume Handle='0' Type='Compartmental' Name='Compartment' />
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='false' Feature='Cytosol' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Nucleus' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Extraclellular' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.1' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='0.5' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.8' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>2.30769</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>3.6923</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>4617.4</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>142857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>4000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>2857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>100.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='Comp Fixed PIP2'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='kBasalSynPIP'>0.0015</Constant>
      <Constant Name='PLC_PM_init'>100.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>0.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='PIP2syndecay'>10.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>1.0</Constant>
      <Constant Name='PIP_basal'>2857.0</Constant>
      <Constant Name='PIPsyndecay'>10.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
      <Constant Name='IP3X_Cytosol'>0.0</Constant>
      <Constant Name='kStimSynPIP'>0.01</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>142857.0</Constant>
      <Constant Name='k_PIP2hyd'>1.188</Constant>
      <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
      <Constant Name='hv_Cytosol'>0.0</Constant>
      <Constant Name='SurfToVol_PM'>0.5</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>2857.0</Constant>
      <Constant Name='PIP2_PM_init'>4000.0</Constant>
      <Constant Name='VolFract_Nucleus'>0.1</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='VolFract_Cytosol'>0.8</Constant>
      <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
      <Constant Name='kStimSynPIP2'>0.01</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='SurfToVol_NM'>1.0</Constant>
      <Constant Name='tauPIPsyn'>0.05</Constant>
      <Constant Name='stim_PM_init'>1.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
      <Constant Name='PIP2_basal'>1072.0</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='kBasalSynPIP2'>0.045</Constant>
      <Constant Name='PIP2_PM'>4000.0</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='k_PIP2PHhyd'>50.0</Constant>
      <Constant Name='tauPIP2syn'>0.05</Constant>
      <VolumeVariable Name='IP3_PHGFP_Cyt' />
      <VolumeVariable Name='PIP2_PHGFP_PM' />
      <VolumeVariable Name='PLC_act_PM' />
      <VolumeVariable Name='PIP_PM' />
      <VolumeVariable Name='PI_PM' />
      <VolumeVariable Name='DAG_PM' />
      <VolumeVariable Name='IP3_Cyt' />
      <Function Name='K_PH_GFP_Cyt_total'>((PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='PH_GFP_Cyt'>(( - (PIP2_PHGFP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Function>
      <Function Name='K_PLC_PM_total'>((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PLC_PM'>((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Function>
      <Function Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Function>
      <Function Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Function>
      <Function Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Function>
      <Function Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Function>
      <Function Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Function>
      <Function Name='Kflux_NM_Nucleus'>SurfToVol_NM</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Function>
      <Function Name='Kflux_NM_Cytosol'>(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Kflux_PM_Cytosol'>(SurfToVol_PM / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Function>
      <Function Name='Kflux_PM_Extraclellular'>(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))</Function>
      <Function Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Function>
      <CompartmentSubDomain Name='Compartment'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <OdeEquation Name='IP3_PHGFP_Cyt'>
          <Rate>J_IP3_PHGFP</Rate>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='IP3_Cyt'>
          <Rate>((RatePIP2_PH_hyd * Kflux_PM_Cytosol * KMOLE) + (Rate_PIP2_hyd * Kflux_PM_Cytosol * KMOLE) - Rate_IP3deg - J_IP3_PHGFP)</Rate>
          <Initial>IP3_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PHGFP_PM'>
          <Rate>(J_PIP2_PH - RatePIP2_PH_hyd)</Rate>
          <Initial>PIP2_PHGFP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PI_PM'>
          <Rate> - Rate_PIPSyn</Rate>
          <Initial>PI_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP_PM'>
          <Rate>( - Rate_PIP2Syn + Rate_PIPSyn)</Rate>
          <Initial>PIP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>(Rate_PIP2_hyd + RatePIP2_PH_hyd)</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
      </CompartmentSubDomain>
      <Version FromVersionable='true' Name='Comp Fixed PIP2'></Version>
    </MathDescription>
    <Simulation Annotation='' Name='Fixed PIP2'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='PIP2_PM'>4000.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed PIP2'></Version>
    </Simulation>
    <Simulation Annotation='' Name='Fixed PIP2 0.3XPH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 0.3)</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 0.3)</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='PIP2_PM'>4000.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 0.3)</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed PIP2 0.3XPH-GFP'></Version>
    </Simulation>
    <Simulation Annotation='' Name='Fixed PIP2 3XPH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 3.0)</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 3.0)</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='PIP2_PM'>4000.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 3.0)</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed PIP2 3XPH-GFP'></Version>
    </Simulation>
    <Simulation Annotation='' Name='Fixed PIP2, Increase PIP2PH affinity'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>0.1</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='PIP2_PM'>4000.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>92307.6</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed PIP2, Increase PIP2PH affinity'></Version>
    </Simulation>
    <Version FromVersionable='true' Name='Comp Fixed PIP2'>(copied from Comp Fixed IP3) (copied from Compartmental Sim) (copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) </Version>
  </SimulationSpec>
  <SimulationSpec CharacteristicSize='0.14276470588235293' Annotation='(copied from Image-based Geom) (copied from Compartmental Sim) (copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) ' Name='Image-based 2D; Fast IP3PH'>
    <Geometry Dimension='2' Annotation='' Name='N1E_for_PIP2'>
      <Extent X='48.54' Y='71.24' Z='1.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <Image Annotation='NoName' Name='N1E for PIP2'>
        <ImageData X='340' Y='499' Z='1' 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3E9BEAB3A93E930664527D060DC8A4FA849A367DA4237D7B2DC1695CE925C6CBA601D934209BEAB3A83E930665D3806C1A9051F5D9549F4D23B2694036D567D2904C1A904D03B26940160DC8A401D934209B0664537D260DC8A40199342093C664D390D23A2C3DD605B26944AF9300C08338E79C73CE39E79C73CE3947F61F5D3DBA9D</ImageData>
        <PixelClass ImagePixelValue='0' Name='EC' />
        <PixelClass ImagePixelValue='127' Name='Cyt' />
        <PixelClass ImagePixelValue='255' Name='Nuc' />
        <Version FromVersionable='true' Name='N1E for PIP2'>NoName</Version>
      </Image>
      <SubVolume Handle='0' Type='Image' ImagePixelValue='0' Name='EC' />
      <SubVolume Handle='1' Type='Image' ImagePixelValue='127' Name='Cyt' />
      <SubVolume Handle='2' Type='Image' ImagePixelValue='255' Name='Nuc' />
      <Version FromVersionable='true' Name='N1E_for_PIP2'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='true' Feature='Cytosol' SubVolume='Cyt'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='true' Feature='Nucleus' SubVolume='Nuc'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='true' Feature='Extraclellular' SubVolume='EC'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.2' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.2' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>1.76923</Initial>
        <Diffusion>50.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>2.8308</Initial>
        <Diffusion>50.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>283.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>3538.46</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>142857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>4000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>2857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>100.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='fast' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='Image-based 2D; Fast IP3PH'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='kBasalSynPIP'>0.0015</Constant>
      <Constant Name='PLC_PM_init'>100.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>0.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='PIP2syndecay'>10.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>1.0</Constant>
      <Constant Name='PIP_basal'>2857.0</Constant>
      <Constant Name='PIPsyndecay'>10.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>2.8308</Constant>
      <Constant Name='IP3X_Cytosol'>0.0</Constant>
      <Constant Name='kStimSynPIP'>0.01</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>142857.0</Constant>
      <Constant Name='k_PIP2hyd'>1.188</Constant>
      <Constant Name='PH_GFP_Cyt_init'>1.76923</Constant>
      <Constant Name='hv_Cytosol'>0.0</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>2857.0</Constant>
      <Constant Name='PIP2_PM_init'>4000.0</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
      <Constant Name='kStimSynPIP2'>0.01</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='tauPIPsyn'>0.05</Constant>
      <Constant Name='stim_PM_init'>1.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>3538.46</Constant>
      <Constant Name='PIP2_basal'>1072.0</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='kBasalSynPIP2'>0.045</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='tauPIP2syn'>0.05</Constant>
      <VolumeVariable Name='IP3_PHGFP' />
      <VolumeVariable Name='PH_GFP' />
      <VolumeVariable Name='IP3' />
      <MembraneVariable Name='PLC_act_PM' />
      <MembraneVariable Name='PIP_PM' />
      <MembraneVariable Name='PI_PM' />
      <MembraneVariable Name='DAG_PM' />
      <MembraneVariable Name='PIP2_PM' />
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='K_PIP2_PHGFP_PM_total'>(DAG_PM_init + PIP_PM_init + PIP2_PM_init + PIP2_PHGFP_PM_init + PI_PM_init)</Function>
      <Function Name='PIP2_PHGFP_PM'>( - DAG_PM - PIP_PM - PIP2_PM + K_PIP2_PHGFP_PM_total - PI_PM)</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_INSIDE) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Function>
      <Function Name='K_PLC_PM_total'>(PLC_PM_init + PLC_act_PM_init)</Function>
      <Function Name='PLC_PM'>(K_PLC_PM_total - PLC_act_PM)</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Function>
      <Function Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Function>
      <Function Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Function>
      <Function Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Function>
      <Function Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Function>
      <Function Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3) * PH_GFP) - (kr_IP3PH * IP3_PHGFP))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3 - IP3_basal))</Function>
      <CompartmentSubDomain Name='EC' Priority='1'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <PdeEquation Name='PH_GFP'>
          <Rate>0.0</Rate>
          <Diffusion>50.0</Diffusion>
          <Initial>0.0</Initial>
        </PdeEquation>
        <PdeEquation Name='IP3_PHGFP'>
          <Rate>0.0</Rate>
          <Diffusion>50.0</Diffusion>
          <Initial>0.0</Initial>
        </PdeEquation>
        <PdeEquation Name='IP3'>
          <Rate>0.0</Rate>
          <Diffusion>283.0</Diffusion>
          <Initial>0.0</Initial>
        </PdeEquation>
      </CompartmentSubDomain>
      <CompartmentSubDomain Name='Cyt' Priority='2'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <PdeEquation Name='PH_GFP'>
          <Rate>0.0</Rate>
          <Diffusion>50.0</Diffusion>
          <Initial>PH_GFP_Cyt_init</Initial>
        </PdeEquation>
        <PdeEquation Name='IP3_PHGFP'>
          <Rate>0.0</Rate>
          <Diffusion>50.0</Diffusion>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </PdeEquation>
        <PdeEquation Name='IP3'>
          <Rate> - Rate_IP3deg</Rate>
          <Diffusion>283.0</Diffusion>
          <Initial>IP3_Cyt_init</Initial>
        </PdeEquation>
        <FastSystem>
          <FastInvariant>(PH_GFP - IP3)</FastInvariant>
          <FastInvariant>(IP3_PHGFP + IP3)</FastInvariant>
          <FastRate> - J_IP3_PHGFP</FastRate>
        </FastSystem>
      </CompartmentSubDomain>
      <CompartmentSubDomain Name='Nuc' Priority='3'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <PdeEquation Name='PH_GFP'>
          <Rate>0.0</Rate>
          <Diffusion>50.0</Diffusion>
          <Initial>0.0</Initial>
        </PdeEquation>
        <PdeEquation Name='IP3_PHGFP'>
          <Rate>0.0</Rate>
          <Diffusion>50.0</Diffusion>
          <Initial>0.0</Initial>
        </PdeEquation>
        <PdeEquation Name='IP3'>
          <Rate>0.0</Rate>
          <Diffusion>283.0</Diffusion>
          <Initial>0.0</Initial>
        </PdeEquation>
      </CompartmentSubDomain>
      <MembraneSubDomain InsideCompartment='Cyt' OutsideCompartment='EC'>
        <OdeEquation Name='PI_PM'>
          <Rate> - Rate_PIPSyn</Rate>
          <Initial>PI_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PM'>
          <Rate>( - Rate_PIP2_hyd - J_PIP2_PH + Rate_PIP2Syn)</Rate>
          <Initial>PIP2_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP_PM'>
          <Rate>( - Rate_PIP2Syn + Rate_PIPSyn)</Rate>
          <Initial>PIP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>Rate_PIP2_hyd</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
        <JumpCondition Name='PH_GFP'>
          <InFlux>(KMOLE * ( - 1.0 * J_PIP2_PH))</InFlux>
          <OutFlux>0.0</OutFlux>
        </JumpCondition>
        <JumpCondition Name='IP3_PHGFP'>
          <InFlux>0.0</InFlux>
          <OutFlux>0.0</OutFlux>
        </JumpCondition>
        <JumpCondition Name='IP3'>
          <InFlux>(KMOLE * Rate_PIP2_hyd)</InFlux>
          <OutFlux>0.0</OutFlux>
        </JumpCondition>
      </MembraneSubDomain>
      <MembraneSubDomain InsideCompartment='Nuc' OutsideCompartment='Cyt'>
        <OdeEquation Name='PI_PM'>
          <Rate>0.0</Rate>
          <Initial>0.0</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PM'>
          <Rate>0.0</Rate>
          <Initial>0.0</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP_PM'>
          <Rate>0.0</Rate>
          <Initial>0.0</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>0.0</Rate>
          <Initial>0.0</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>0.0</Rate>
          <Initial>0.0</Initial>
        </OdeEquation>
        <JumpCondition Name='PH_GFP'>
          <InFlux>0.0</InFlux>
          <OutFlux>0.0</OutFlux>
        </JumpCondition>
        <JumpCondition Name='IP3_PHGFP'>
          <InFlux>0.0</InFlux>
          <OutFlux>0.0</OutFlux>
        </JumpCondition>
        <JumpCondition Name='IP3'>
          <InFlux>0.0</InFlux>
          <OutFlux>0.0</OutFlux>
        </JumpCondition>
      </MembraneSubDomain>
      <Version FromVersionable='true' Name='Image-based 2D; Fast IP3PH'></Version>
    </MathDescription>
    <Simulation Annotation='' Name='Image; Fast 1'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='Finite Volume, Regular Grid' KeepEvery='500'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-8' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>1.76923</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>2.8308</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>3538.46</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
      </MathOverrides>
      <MeshSpecification>
        <Size X='58' Y='86' Z='1' />
      </MeshSpecification>
      <Version FromVersionable='true' Name='Image; Fast 1'></Version>
    </Simulation>
    <Simulation Annotation='1s test to check ss before 50ms' Name='Image; Fast 2'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='Finite Volume, Regular Grid' KeepEvery='5'>
        <TimeBound StartTime='0.0' EndTime='1.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-8' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>1.76923</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>2.8308</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>3538.46</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
      </MathOverrides>
      <MeshSpecification>
        <Size X='58' Y='86' Z='1' />
      </MeshSpecification>
      <Version FromVersionable='true' Name='Image; Fast 2'>1s test to check ss before 50ms</Version>
    </Simulation>
    <Simulation Annotation='1s test to check if shorter timestep is required' Name='Image; Fast 3'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='Finite Volume, Regular Grid' KeepEvery='50'>
        <TimeBound StartTime='0.0' EndTime='1.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-8' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>1.76923</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>2.8308</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>3538.46</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
      </MathOverrides>
      <MeshSpecification>
        <Size X='58' Y='86' Z='1' />
      </MeshSpecification>
      <Version FromVersionable='true' Name='Image; Fast 3'>1s test to check if shorter timestep is required</Version>
    </Simulation>
    <Simulation Annotation='4X membrane species except PLC, to account for 3D S:V&amp;#10;This has the effect of increasing the rate of production of IP3 without affecting&amp;#10; the relative rates of change of membrane species&amp;#10;All membrane variables will be divided by 4 to correct for this in the presentation of the data' Name='Image; Fast 4'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='Finite Volume, Regular Grid' KeepEvery='500'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-8' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PI_PM_init'>(142857.0 * 4.0)</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>1.76923</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>2.8308</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(3538.46 * 4.0)</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='PIP2_basal'>(4000.0 * 4.0)</Constant>
        <Constant Name='PIP2_PM_init'>(4000.0 * 4.0)</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PIP_basal'>(2857.0 * 4.0)</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='PIP_PM_init'>(2857.0 * 4.0)</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
      </MathOverrides>
      <MeshSpecification>
        <Size X='58' Y='86' Z='1' />
      </MeshSpecification>
      <Version FromVersionable='true' Name='Image; Fast 4'>4X membrane species except PLC, to account for 3D S:V&amp;#10;This has the effect of increasing the rate of production of IP3 without affecting&amp;#10; the relative rates of change of membrane species&amp;#10;All membrane variables will be divided by 4 to correct for this in the presentation of the data</Version>
    </Simulation>
    <Simulation Annotation='4X membrane species to account for 3D S:V&amp;#10;No PH-GFP' Name='Image; Fast 5'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='Finite Volume, Regular Grid' KeepEvery='500'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-8' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PI_PM_init'>(142857.0 * 4.0)</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>0.0</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>0.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='PIP2_basal'>(4000.0 * 4.0)</Constant>
        <Constant Name='PIP2_PM_init'>(4000.0 * 4.0)</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PIP_basal'>(2857.0 * 4.0)</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='PIP_PM_init'>(2857.0 * 4.0)</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
      </MathOverrides>
      <MeshSpecification>
        <Size X='58' Y='86' Z='1' />
      </MeshSpecification>
      <Version FromVersionable='true' Name='Image; Fast 5'>4X membrane species to account for 3D S:V&amp;#10;No PH-GFP</Version>
    </Simulation>
    <Simulation Annotation='4X membrane species to account for 3D S:V&amp;#10;No PH-GFP&amp;#10;Higher spatial resolution' Name='Image; Fast 6'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='Finite Volume, Regular Grid' KeepEvery='2500'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-8' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PI_PM_init'>(142857.0 * 4.0)</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>0.0</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>0.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='PIP2_basal'>(4000.0 * 4.0)</Constant>
        <Constant Name='PIP2_PM_init'>(4000.0 * 4.0)</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PIP_basal'>(2857.0 * 4.0)</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='PIP_PM_init'>(2857.0 * 4.0)</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
      </MathOverrides>
      <MeshSpecification>
        <Size X='116' Y='172' Z='1' />
      </MeshSpecification>
      <Version FromVersionable='true' Name='Image; Fast 6'>4X membrane species to account for 3D S:V&amp;#10;No PH-GFP&amp;#10;Higher spatial resolution</Version>
    </Simulation>
    <Version FromVersionable='true' Name='Image-based 2D; Fast IP3PH'>(copied from Image-based Geom) (copied from Compartmental Sim) (copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) </Version>
  </SimulationSpec>
  <Version FromVersionable='true' Name='PIP2 Hydrolysis JCB Submission'>This model is intended for anlaysis of PH-GFP experiments and includes binding of the probe to both PIP2 on the plasma membrane and IP3 in the cytosol. The system is based on bradykinin induced calcium release mediated by IP3 in N1E-115 neuroblastoma cells.</Version>
</BioModel>